Mechanotransduction of fluid stresses governs 3D cell migration

Mechanotransduction of fluid stresses governs 3D cell migration.

Solid tumors are characterized by high interstitial fluid pressure, which drives fluid efflux from the tumor core. Tumor-associated interstitial flow (IF) at a rate of ∼3 µm/s has been shown to induce cell migration in the upstream direction (rheotaxis). However, the molecular biophysical mechanism that underlies upstream cell polarization and rheotaxis remains unclear. We developed a microflui...

Mechanotransduction in endothelial cell migration.

The migration of endothelial cells (ECs) plays an important role in vascular remodeling and regeneration. EC migration can be regulated by different mechanisms such as chemotaxis, haptotaxis, and mechanotaxis. This review will focus on fluid shear stress-induced mechanotransduction during EC migration. EC migration and mechanotransduction can be modulated by cytoskeleton, cell surface receptors...

Role of Intermediate Filaments in Mechanotransduction during Cell Migration

Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels.

The spatial presentation of mechanical information is a key parameter for cell behavior. We have developed a method of polymerization control in which the differential diffusion distance of unreacted cross-linker and monomer into a prepolymerized hydrogel sink results in a tunable stiffness gradient at the cell-matrix interface. This simple, low-cost, robust method was used to produce polyacryl...

3D Investigation of Tubular PEM Fuel Cell Performance Assuming Fluid- Solid- Heat Interaction

According to the declining trend of fossil fuel resources and the need to use renewable energies, appropriate research should be conducted for technical and functional studies in this regard. Therefore, in this research, a tubular PEM fuel  cell as a suitable energy source with three-dimensional geometry has been numerically simulated and investigated. For a comprehensive study, the equations o...